[Progress of polymorphism in microRNA and microRNA target sites]
Li-Ying Liu1, Ji-Ru Xu, Tu-Sheng Song
1Key Laboratory of Environment and Genes Related to Diseases Ministry of Education, the Central Laboratory for Biomedical Research, Medical School, Xi'an Jiaotong University, Xi 'an 710061, China. llying@mail.xjtu.edu.cn
Abstract:
MicroRNAs (miRNAs), which are evolutionarily well-conserved, 21- to 23-nucleotide-long, small non-coding RNAs, are widely involved in the regulation of multiple biological processes, such as development, organogenesis, cell proliferation, cell differentiation, and apoptosis. Recent studies have shown that polymorphism in miRNAs and their target sites are closely related to various diseases, such as tumor and cardiological diseases. This review introduces recent progresses on polymorphism in microRNAs and their targeting sites and the related diseases.
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