Related Experiment Video

Updated: Jun 2, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

[Research advances on RB1 gene]

Shuang-Hu Liu1, Shou-Zhi Wang, Hui Zhang

  • 1College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. sunyboy147@163.com

Yi Chuan = Hereditas
|April 26, 2011
PubMed

Insights

The retinoblastoma1 (RB1) gene, a key tumor suppressor, regulates the cell cycle. This review covers recent findings on RB1 gene structure, expression, and its critical functions in cell growth and development.

Area of Science:

  • Molecular Biology
  • Cancer Genetics
  • Cell Biology

Background:

  • The retinoblastoma1 (RB1) gene is the first tumor suppressor gene to be cloned.
  • RB1 functions as a critical negative regulator of the cell cycle.
  • Its role is essential in maintaining cellular homeostasis and preventing uncontrolled proliferation.

Purpose of the Study:

  • To review recent advancements in the understanding of the RB1 gene.
  • To summarize the current knowledge on RB1 gene structure, expression, and function.
  • To highlight RB1's involvement in fundamental cellular processes.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies focusing on RB1 gene structure and expression.
  • Synthesis of research on RB1's functional roles in cell cycle regulation.

Main Results:

  • RB1 protein binds to transcription factors, influencing gene expression.
  • RB1 regulates genes involved in cell proliferation and differentiation.
  • RB1 is implicated in cell cycle control, senescence, growth arrest, and apoptosis.

Conclusions:

  • The RB1 gene is a pivotal tumor suppressor with multifaceted roles.
  • Understanding RB1's structure, expression, and function is crucial for cancer research.
  • Continued investigation into RB1 pathways may yield therapeutic strategies.

More Related Videos

Reconstruct Human Retinoblastoma In Vitro06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.07:46

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.

Published on: December 11, 2020

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...