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Related Concept Videos

Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Bacteriophages of the Human Virome01:23

Bacteriophages of the Human Virome

Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Horizontal Gene Transfer01:27

Horizontal Gene Transfer

Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

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Related Experiment Video

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

[The human variome project and its progress].

Shan Gao1, Ning Zhang, Lei Zhang

  • 1College of Life Science, Nankai University, Tianjin 300071, China. gao_shan@mail.nankai.edu.cn

Yi Chuan = Hereditas
|April 26, 2011
PubMed
Summary
This summary is machine-generated.

The Human Variome Project (HVP) collects human genome variation data to identify disease-causing mutations. This research aims to translate genetic findings into clinical applications for improved human health.

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Last Updated: Jun 2, 2026

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Area of Science:

  • Genomics and post-genomic research.
  • Integration of multiple omics disciplines.
  • Human genetics and disease association studies.

Context:

  • The Human Genome Project provided a foundational genome map.
  • Post-genomic era focuses on genome function and variation.
  • The Human Genome Variation Society (HGVS) launched the HVP in 2006.

Purpose:

  • To establish a comprehensive global collection of human sequence variation and polymorphism data.
  • To identify mutations linked to human diseases through genotype-phenotype association studies.
  • To advance the understanding of genome-level variations and their impact on health.

Summary:

  • The Human Variome Project (HVP) aims to catalog all human genetic variations.
  • It employs genome-wide association studies to link genetic mutations to diseases.
  • The project seeks to translate genetic discoveries into practical clinical applications.

Impact:

  • Potential to significantly improve understanding of human diseases.
  • Facilitates the translation of genetic research into clinical practice.
  • Enhances the clinical application of genomic data for patient benefit.