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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
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Ceramic-based microelectrode arrays: recording surface characteristics and topographical analysis.

Pooja M Talauliker1, David A Price, Jason J Burmeister

  • 1Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA. pooja.talauliker@uky.edu

Journal of Neuroscience Methods
|April 26, 2011
PubMed
Summary
This summary is machine-generated.

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Microelectrode arrays (MEAs) fabricated with platinum (Pt°) exhibit unique microwell geometries and nanoscale surface textures. These physical properties enhance current density, potentially improving in vivo neuromolecule recording performance.

Area of Science:

  • Neuroscience
  • Materials Science
  • Biomedical Engineering

Background:

  • Microelectrode arrays (MEAs) are crucial for in vivo neuromolecule measurement.
  • Previous studies focused on MEA functionality, not intrinsic physical properties.
  • Understanding MEA physical characteristics is key to optimizing electrochemical recording.

Purpose of the Study:

  • To characterize the intrinsic physical properties of photolithographically fabricated platinum (Pt°) microelectrode arrays (MEAs).
  • To correlate physical features with potential electrochemical recording performance.
  • To establish a baseline for understanding MEA behavior in vivo.

Main Methods:

  • Spectral analysis to determine recording site composition (elemental platinum, Pt°).

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Last Updated: Jun 2, 2026

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  • Scanning electron microscopy (SEM) to analyze microwell geometry.
  • Atomic force microscopy (AFM) to characterize surface topography at the nanoscale.

    • Main Results:

    • Confirms Pt° composition of recording sites.
    • Reveals unique microwell geometries due to photolithography.
    • Demonstrates nanoscale surface irregularities (elevations/depressions) increasing current per area.
    • Characterizes ceramic substrate texture and side morphology.

    Conclusions:

    • Photolithographically fabricated Pt MEAs possess unique Pt° composition and surface profiles.
    • Nanoscale surface features increase current density beyond previous designs.
    • These physical properties are critical for understanding biological molecule adhesion and in vivo electrochemical performance.