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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Feb 8, 2026

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
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Siliconomas mimicking cancer.

Ahuva Grubstein1, Maya Cohen, Adam Steinmetz

  • 1Mammography Clinic, Department of Radiology, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel. ahuva.efi@gmail.com

Clinical Imaging
|April 26, 2011
PubMed
Summary

Silicone granulomas from ruptured breast implants can mimic malignancy on PET CT and MRI scans. Awareness of these imaging findings is crucial for accurate diagnosis in patients with implants.

Area of Science:

  • Radiology
  • Oncology
  • Pathology

Background:

  • Silicone breast implants are common for augmentation and reconstruction.
  • Implant rupture presents specific radiological signs.
  • Advanced imaging like PET CT and MRI can mimic malignancy.

Observation:

  • Retrospective review of four patients with silicone implants presenting with suspected malignancy on PET CT or MRI.
  • Two cases showed benign silicone granulomas with increased FDG uptake on PET CT.
  • One case had a suspicious mass on MRI, later found to be a benign tissue response.
  • Another case showed bilateral ruptured implants with lymphadenopathy, leading to a sarcoidosis diagnosis.

Findings:

  • Silicone granulomas can appear as masses with suspicious morphology and enhancement on MRI.

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  • Increased fluorodeoxyglucose (FDG) uptake on PET CT can indicate silicone granulomas.
  • Ruptured implants and silicone granulomas can present with findings mimicking cancer.

    • Implications:

    • Radiologists and oncologists must consider silicone implant complications when interpreting imaging.
    • Awareness of silicone granuloma imaging characteristics aids in avoiding misdiagnosis of malignancy.
    • Proper identification of implant-related findings is essential for correct patient management.