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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Related Experiment Video

Updated: Jun 2, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Published on: April 5, 2018

The PHD finger: a versatile epigenome reader.

Roberto Sanchez1, Ming-Ming Zhou

  • 1Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA. roberto.sanchez@mssm.edu

Trends in Biochemical Sciences
|April 26, 2011
PubMed
Summary
This summary is machine-generated.

Plant homeodomain (PHD) zinc fingers are crucial for gene transcription by reading histone modifications. Evolutionary changes in PHD fingers create diverse functions in epigenome regulation.

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Last Updated: Jun 2, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

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Published on: April 5, 2018

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Published on: August 13, 2020

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07:28

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Published on: January 23, 2019

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Plant homeodomain (PHD) zinc fingers are conserved protein modules involved in gene transcription.
  • Their function was initially linked to recognizing lysine-methylated histone H3.
  • Emerging evidence highlights their role in mediating molecular interactions within chromatin.

Purpose of the Study:

  • To explore the sophisticated histone sequence reading capacity of PHD fingers.
  • To understand how histone modifications modulate PHD finger function.
  • To emphasize the role of PHD fingers as epigenome readers in gene expression control.

Main Methods:

  • Analysis of recent studies on PHD finger function.
  • Investigating the interplay between different histone modifications.
  • Examining the recruitment of chromatin regulators and transcription factors.

Main Results:

  • PHD fingers possess a complex ability to read histone sequences.
  • Histone modifications dynamically regulate PHD finger activity.
  • PHD fingers act as crucial readers in the epigenome, controlling gene expression.

Conclusions:

  • PHD fingers are versatile epigenome readers essential for gene regulation.
  • Evolutionary alterations in amino acids around ligand-binding sites confer functional diversity.
  • Understanding PHD finger mechanisms is key to deciphering gene transcription control.