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Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
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The contribution of GABAergic dysfunction to neurodevelopmental disorders

Kartik Ramamoorthi1, Yingxi Lin

  • 1McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Trends in Molecular Medicine
|April 26, 2011
PubMed
Summary

GABA (γ-aminobutyric acid) is key for brain E/I balance. Disruptions in GABAergic development cause neurodevelopmental disorders, but targeting this system may offer effective treatments.

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