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Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System
Published on: April 25, 2025
Development of a pyrosequencing assay for rapid assessment of quinolone resistance in Acinetobacter baumannii
Yann Deccache1, Léonid M Irenge, Encho Savov
1Defence Laboratories Department, Belgian Armed Forces, Brussels, Belgium.
Journal of Microbiological Methods
|April 26, 2011
Abstract:
Rapid and reliable assessment of Acinetobacter baumannii resistance to quinolones was successfully achieved through pyrosequencing of the gyrA and parC quinolone-resistance determining regions. A strong correlation was found between quinolone resistance and mutations in gyrA codon 83 and/or in the parC gene (codons 80 or 84). Absence of QRDR mutations was associated with susceptibility to quinolones.
