Related Experiment Video
Updated: Jun 2, 2026
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Published on: April 7, 2023
A dose-finding study of oral misoprostol for labor augmentation
Kathryn S Villano1, Julie Y Lo, James M Alexander
1Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, USA. Kathryn.Villano@gmail.com
Objective:
We designed a dose-finding trial of oral misoprostol administered for labor augmentation.
Study Design:
Healthy, nulliparous women in active labor and diagnosed with arrest of dilation were enrolled in cohorts of 10 at a time. Five regimens were studied: (1) 25 μg every 4 hours, (2) 50 μg every 4 hours, (3) 100 μg every 4 hours, (4) 50 μg every 2 hours, and (5) 75 μg every 4 hours.
Results:
A total of 46 women were enrolled. Baseline uterine activity approximately doubled with 4 of the regimens and tripled with the highest dosage regimen (100 μg) (P < .001). The 100-μg regimen was truncated due to excessive uterine hyperstimulation (40%).
Conclusion:
An oral dose of 75 μg of misoprostol given at a 4-hour interval for a maximum of 2 doses is the highest tolerated dose. Randomized, controlled trials will be required before a regimen is employed routinely.
Related Concept Videos
01:20Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
01:21Intrauterine Drug Delivery Systems
01:11Bioavailability Study Design: Single Versus Multiple Dose Studies