Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Collagen nanofiber reinforced alginate hydrogel tube microbioreactors for cell culture.

Frontiers in bioengineering and biotechnology·2026

Same author

The intravenous targeted nanopeptide, CAQK, is neuroprotective and improves motor function after spinal cord injury in rats.

The journal of trauma and acute care surgery·2026

Same author

Cross-modal training reduced susceptibility to the sound-induced flash illusion and generalized across stimulus onset asynchronies.

Psychological research·2026

Same author

Treatment Effects of Bisphosphonates Compared to Oxandrolone on Burn-Induced Bone Loss and Recovery in Mice.

Journal of orthopaedic trauma·2026

Same author

How background music rhythm modulates time perception: Evidence from the estimation of collision time.

Attention, perception & psychophysics·2026

Same author

Perceptual distraction causes attentional but outdated information to intrude into working memory.

Attention, perception & psychophysics·2026

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

Induced pluripotent stem cells for neural tissue engineering.

Aijun Wang¹, Zhenyu Tang, In-Hyun Park

¹Department of Bioengineering, University of California, Berkeley, B108A Stanley Hall, Berkeley, CA 94720-1762, USA.

|April 26, 2011

Summary

This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) can generate neural crest stem cells (NCSCs) for neural tissue engineering. NCSC-loaded scaffolds accelerate nerve regeneration and promote myelination without teratoma formation.

More Related Videos

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Published on: April 23, 2014

Related Experiment Videos

Last Updated: Jun 2, 2026

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Published on: April 23, 2014

Area of Science:

Regenerative Medicine
Stem Cell Biology
Neural Engineering

Background:

Induced pluripotent stem cells (iPSCs) offer potential for cell therapies.
Neural crest stem cells (NCSCs) are multipotent and valuable for studying differentiation.
Investigating NCSC potential in neural tissue engineering is crucial.

Purpose of the Study:

To derive NCSCs from human iPSCs and ESCs.
To evaluate the therapeutic potential of NCSCs for neural tissue engineering.
To assess NCSC integration and function in a nerve regeneration model.

Main Methods:

Derivation of NCSCs from human iPSCs and ESCs.
Fabrication of tissue-engineered nerve conduits using NCSCs and nanofibrous scaffolds.
Assessment of nerve regeneration in a rat sciatic nerve transection model using electrophysiological and histological analyses.
In vivo safety evaluation for teratoma formation.

Main Results:

NCSC lines derived from iPSCs and ESCs differentiated into neural cells.
NCSC-engrafted nerve conduits significantly accelerated sciatic nerve regeneration at 1 month.
NCSC transplantation promoted axonal myelination, with NCSCs differentiating into Schwann cells and integrating into the myelin sheath.
No teratoma formation was observed up to 1 year post-transplantation.

Conclusions:

iPSC-derived NCSCs are suitable for direct use in neural tissue engineering.
Combining stem cells with scaffolds shows significant potential for regenerative medicine applications.
NCSC transplantation is a safe and effective strategy for promoting nerve repair.