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Fibrinolytic defect and chronic low-back pain.

J G Previnaire1, L Plaghki, C Col-de Beys

  • 1Department of Physical Medicine and Rehabilitation, Cliniques Universitaires St. Luc, Brussels, Belgium.

Acta Belgica. Medica Physica : Organe Officiel De La Societe Royale Belge De Medecine Physique Et De Rehabilitation
|October 1, 1990
PubMed
Summary

A fibrinolytic defect is common in chronic low-back pain patients, particularly those with arachnoiditis. A venous occlusion test aids in detecting this defect.

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Area of Science:

  • Medical Research
  • Hematology
  • Neurosurgery

Background:

  • Chronic low-back pain affects a significant population, often with associated leg pain.
  • Fibrinolytic activity plays a role in vascular health and may be implicated in pain conditions.
  • Arachnoiditis, inflammation of the arachnoid mater, is a known complication that can cause persistent pain.

Purpose of the Study:

  • To investigate the prevalence of fibrinolytic defects in patients with chronic low-back pain.
  • To determine the association between fibrinolytic defects and the presence of arachnoiditis.
  • To evaluate the utility of a venous occlusion test in identifying fibrinolytic defects.

Main Methods:

  • Fifty-five patients with chronic low-back pain underwent a 10-minute venous occlusion test to assess fibrinolytic activity.

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  • Diagnosis of arachnoiditis was confirmed through direct surgical observation or advanced imaging (myelography and CT scan).
  • Fibrinolytic activity was measured following the occlusion test.

    • Main Results:

    • A fibrinolytic defect was identified in 45% (25/55) of patients with chronic low-back pain.
    • The prevalence of fibrinolytic defects was significantly higher in patients with arachnoiditis, at 75% (18/24).
    • The venous occlusion test demonstrated effectiveness in enhancing the detection sensitivity for fibrinolytic defects.

    Conclusions:

    • Fibrinolytic defects are not uncommon in individuals experiencing chronic low-back pain.
    • There is a strong correlation between fibrinolytic defects and the presence of arachnoiditis.
    • The venous occlusion test is a valuable tool for improving the diagnosis of fibrinolytic defects in this patient group.