Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Types of Errors: Detection and Minimization01:12

Types of Errors: Detection and Minimization

Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Application of a Deep Learning Algorithm for the Segmentation of Retinal Nerve Fiber Layer Across Different Optic Neuropathies.

Translational vision science & technology·2026
Same author

Optic nerve sheath meningiomas harbor distinct genetic variants.

American journal of clinical pathology·2026
Same author

From Observation to Prediction: Machine Learning Analysis of Progression of Visual loss in Nonarteritic Anterior Ischemic Optic Neuropathy.

American journal of ophthalmology·2026
Same author

Traumatic Optic Neuropathy-Craniofacial Fracture Patterns and Management.

Annals of plastic surgery·2026
Same author

Progression of Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Occurs Early and Is Unassociated With Modifiable Risk Factors.

American journal of ophthalmology·2026
Same author

Neuro-ophthalmic clues affecting the surgical approach to a brain tumor: the case of a craniopharyngioma masquerader.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2025

Related Experiment Video

Updated: Jun 2, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

Checking for plagiarism, duplicate publication, and text recycling

Neil R Miller

    Lancet (London, England)
    |April 26, 2011
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
    07:50

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

    Published on: April 18, 2025

    Related Experiment Videos

    Last Updated: Jun 2, 2026

    Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
    05:02

    Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

    Published on: October 24, 2019

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
    07:50

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

    Published on: April 18, 2025