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Updated: Sep 9, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
[Periodontal disease in Down's syndrome]
Abstract:
During the next decade the number of persons with Down's syndrome is expected to rise; in addition, a smaller proportion of them will be institutionalized. Therefore, the number of patients with this syndrome calling on the general dental practitioner for treatment will be increasing. Epidemiological investigations show a high prevalence and a rapid progression of periodontal disease in persons with Down's syndrome. These periodontal problems are related to their diminished immunological response. The severity of the disease is indicated by the fact that 70% of the edentulous persons with Down's syndrome in institutions lost their dentition because of extraction due to periodontal destruction. This constitutes a sharp contrast with the normal population, where this percentage is less than 1. Characteristic clinical symptoms of this disease entity are described and their therapeutic measures indicated. Preventive measures are advocated, including chemical plaque control when the general immunological resistance of the individual is diminished.
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