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Updated: Jun 2, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Role of p63 in cancer development
Vincenzo Graziano1, Vincenzo De Laurenzi
1Dipartimento di Scienze Biomediche, Universita"G. d'Annunzio" Chieti-Pescara, Via Colle dell'Ara 1, 66100 Chieti, Italy.
Abstract:
Since their initial identification p53 homologues p63 and p73 have been expected to play a role in cancer development due to their close homology to p53, notoriously one of the most mutated genes in cancer. However soon after their discovery the awareness that these genes were rarely mutated in cancer seemed to indicate that they did not play a role in its development. However a large number of data collected in the following years indicated that altered expression rather than mutation could be found in different neoplasia and play a role in its biology. In particular p63 due to its fundamental role in epithelial development seems to play a role in a number of tumors of epithelial origin. In this review we summarize some of the evidence linking p63 to carcinogenesis.
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