Simultaneous controlled vitamin release from multiparticulates: theory and experiment.

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Chemical Engineering

Background:

• Simultaneous delivery of multiple vitamins with diverse physicochemical properties presents formulation challenges.
• Controlling the release kinetics of various vitamins from a single dosage form is crucial for therapeutic efficacy.

Purpose of the Study:

• To investigate the simultaneous control of release for multiple vitamins with differing solubilities and molecular weights from multiparticulates.
• To explore the use of sucrose esters and triglycerides as matrix formers for controlled vitamin release.

Main Methods:

• Multiparticulate granules were prepared using wet granulation, melt granulation, or compression and grinding techniques.
• Sucrose esters (Sucrose Stearate S370, S1170) and triglycerides (glycerol dibehenate, dipalmitostearate) were employed as matrix formers.
• Vitamin release kinetics were assessed in various media (0.1N HCl, pH 6.8 phosphate buffer, water) using a USP paddle apparatus.

Main Results:

• Simultaneous control over the release rates of nicotinamide, pyridoxine hydrochloride, riboflavin 5'-phosphate, riboflavin, thiamine chloride hydrochloride, and thiamine nitrate was achieved.
• Release rates were successfully adjusted by modifying vitamin content, granule size, preparation method, and matrix former type.
• Diffusion was identified as the primary mass transport mechanism in most investigated systems.

Conclusions:

• The study successfully demonstrated the ability to simultaneously control the release of multiple vitamins from multiparticulates.
• Fick's law solutions can be utilized to predict and optimize vitamin release patterns based on formulation and system design.
• This research provides valuable insights for the development of advanced drug delivery systems for multi-component therapies.