Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Truncation in Survival Analysis01:09

Truncation in Survival Analysis

Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are observed.
Quadratic Models01:23

Quadratic Models

Quadratic models are mathematical representations used to describe relationships in which the rate of change changes at a constant rate. These models appear in a wide variety of natural and engineered systems, especially those involving motion, forces, and optimization. One common application is analyzing the vertical motion of objects influenced by gravity, such as a ball thrown into the air.In such scenarios, the object's height changes over time in a curved pattern, rising to a maximum point...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Regression Analysis01:11

Regression Analysis

Regression analysis is a statistical tool that describes a mathematical relationship between a dependent variable and one or more independent variables.
In regression analysis, a regression equation is determined based on the line of best fit– a line that best fits the data points plotted in a graph. This line is also called the regression line. The algebraic equation for the regression line is called the regression equation. It is represented as:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of traditional Chinese medicine in treating severe pneumonia: A meta-analysis and systematic review.

Medicine·2026
Same author

Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2025
Same author

The relationship of social determinants of health and school nurse presence on chronic absenteeism.

Nursing outlook·2025
Same author

Frequent seizure and epilepsy-related emergency department visits in the United States: A retrospective cohort study.

Epilepsia·2025
Same author

Using Joint Models to Find What Worked Best in ISCHEMIA: Setting a New Standard.

Journal of the American College of Cardiology·2025
Same author

The prognosis prediction value of CD69+ CD8+ tissue-resident memory T cell as a novel indicator of pathologic complete response heterogeneity following different neoadjuvant therapy regimen in esophageal squamous cell carcinoma.

Cancer immunology, immunotherapy : CII·2025
Same journal

Modeling Disease-specific Survival in Observational Studies with Missing Cause of Death: Leveraging Information from Clinical Trial Data.

Computational statistics & data analysis·2026
Same journal

A simultaneous confidence-bounded true discovery proportion perspective on localizing differences in smooth terms in regression models.

Computational statistics & data analysis·2025
Same journal

MIXANDMIX: numerical techniques for the computation of empirical spectral distributions of population mixtures.

Computational statistics & data analysis·2024
Same journal

Locally sparse quantile estimation for a partially functional interaction model.

Computational statistics & data analysis·2024
Same journal

Flexible Regularized Estimation in High-Dimensional Mixed Membership Models.

Computational statistics & data analysis·2024
Same journal

GPU Accelerated Estimation of a Shared Random Effect Joint Model for Dynamic Prediction.

Computational statistics & data analysis·2024
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Penalized spline estimation for functional coefficient regression models.

Yanrong Cao1, Haiqun Lin, Tracy Z Wu

  • 1Manulife Financial, 200 Bloor St. E., Toronto, ON M4W1E5, Canada.

Computational Statistics & Data Analysis
|April 26, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces penalized splines for functional coefficient regression models, offering efficient estimation, inference, and forecasting for dependent data. The P-spline method provides computational stability and explicit model expressions for practical applications.

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Related Experiment Videos

Last Updated: Jun 2, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Area of Science:

  • Statistics
  • Econometrics
  • Data Science

Background:

  • Functional coefficient regression models capture dynamic relationships by allowing coefficients to vary.
  • Traditional methods can struggle with high-dimensional data (curse of dimensionality).
  • Existing approaches may lack computational efficiency or explicit model forms for forecasting.

Purpose of the Study:

  • To develop and investigate penalized spline (P-spline) methods for functional coefficient regression with dependent observations.
  • To provide efficient estimation, inference, and multi-step-ahead forecasting capabilities.
  • To explore and compare various smoothing parameter selection techniques.

Main Methods:

  • Utilized penalized splines (P-splines) for estimating functional coefficient regression models.
  • Employed fixed-knot asymptotics for statistical inference.
  • Investigated smoothing parameter selection using modified multi-fold cross-validation (MCV), generalized cross-validation (GCV), empirical bias bandwidth selection (EBBS), and restricted maximum likelihood (REML).

Main Results:

  • The P-spline approach demonstrated computational efficiency and stability.
  • Established fixed-knot asymptotics facilitate readily available inference, including exact inference for fixed smoothing parameters.
  • The method allows for different smoothness levels for individual functional coefficients via distinct penalty parameters.
  • Multi-step-ahead forecasting is enabled through explicit model expressions.

Conclusions:

  • Penalized splines offer a flexible and efficient framework for functional coefficient regression, particularly with dependent data.
  • The proposed methods provide robust estimation, inference, and forecasting capabilities.
  • The study validates the approach through simulations and a real-world data application.