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Updated: Jun 2, 2026
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Xenotransplantation of breast cancers
Massimiliano Cariati1, Rebecca Marlow, Gabriela Dontu
1Department of Research Oncology, School of Medicine, King’s College London, London, UK.
Abstract:
Three experimental systems based on mouse models are currently used to study breast cancer: transgenic mice, carcinogen-induced models, and xenografts of breast cancers. Each of these models has advantages and limitations. This chapter focuses on xenotransplantation of breast cancers and reviews the techniques used so far in establishing this model, the advantages and limitations compared to other experimental systems, and finally, the technical questions that remain to be answered.
