Related Experiment Video

Updated: Jun 2, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

[Coronary artery necroses and calcification in chronic ischemic heart disease]

V S Zhdanov, N M Cherpachenko, I P Drobkova

    Terapevticheskii Arkhiv
    |April 27, 2011
    PubMed

    Insights

    Coronary artery calcification (CAC) mechanisms were studied in 150 patients. Two CAC types were identified: one linked to plaque masses, another to fibrous plaque necroses, typical in chronic coronary heart disease (CHD).

    Area of Science:

    • Cardiovascular Pathology
    • Atherosclerosis Research

    Background:

    • Coronary artery calcification (CAC) is a hallmark of coronary heart disease (CHD).
    • Mechanisms of CAC development, particularly those independent of atherosclerotic plaque calcification, require further investigation.

    Purpose of the Study:

    • To elucidate inadequately studied mechanisms of coronary artery calcification (CAC).
    • To differentiate CAC types and their association with atherosclerotic plaque characteristics in chronic CHD.

    Main Methods:

    • Pathomorphological analysis of endarterectomized coronary artery (CA) segments from 150 patients (aged 49-72) with CHD.
    • Identification and characterization of two distinct types of CAC based on their association with atherosclerotic plaques.

    Main Results:

    • CAC was prevalent (92%) in the studied CA segments.
    • Two CAC types were observed: associated with calcified atheromatous masses and related to necroses in fibrous plaque regions.
    • Lamellar calcification, often linked to plaque instability (23.3% of cases), was associated with fibrous plaque necroses in chronic CHD.

    Conclusions:

    • Calcification within necrotic areas of fibrous plaque parts is characteristic of chronic CHD.
    • This type of calcification frequently presents as large-focal deposits, forming lamellar structures (lamellar calcification).
    • Impaired transmural plasma perfusion is implicated in the development of necroses within stenotic CA atherosclerotic plaques.
    Abstract

    More Related Videos

    Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

    Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

    Published on: May 31, 2016

    Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans04:40

    Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

    Published on: August 28, 2018

    Related Concept Videos

    Coronary Artery Disease II: Pathophysiology01:26

    Coronary Artery Disease II: Pathophysiology

    Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
    Coronary Artery Disease III: Clinical Manifestations01:30

    Coronary Artery Disease III: Clinical Manifestations

    Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

    The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
    Coronary Artery Disease I: Introduction01:30

    Coronary Artery Disease I: Introduction

    Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
    Ischemic Heart Disease: Overview01:17

    Ischemic Heart Disease: Overview

    Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
    Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
    Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

    Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

    Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...