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[Functional condition of the stomach, pancreas, liver and gallbladder in celiac disease]

L M Krums, E A Sabel'nikova, A I Parfenov

    Terapevticheskii Arkhiv
    |April 27, 2011
    PubMed

    Insights

    Celiac disease (CD) significantly impacts digestive organs, causing stomach issues, pancreatic enzyme decline, and gallbladder dysfunction. These contribute to malabsorption and other CD symptoms.

    Area of Science:

    • Gastroenterology
    • Pediatric Gastroenterology
    • Digestive System Physiology

    Background:

    • Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
    • Understanding gastrointestinal manifestations beyond the small intestine is crucial for comprehensive CD management.

    Purpose of the Study:

    • To investigate the condition of the stomach, gallbladder, pancreas, and liver in celiac disease patients.
    • To determine the contribution of dysfunction in these organs to the clinical presentation of CD symptoms.

    Main Methods:

    • Studied 215 celiac disease patients and 25 healthy controls.
    • Assessed gastric acid secretion, gastrin levels, pancreatic enzyme activity (trypsin, amylase, lipase), and bile acid composition.
    • Utilized duodenal intubation, biochemical assays, liver biopsy, and histological examination.

    Main Results:

    • Celiac disease patients exhibited high gastric acid secretion and gastrin levels, with lymphocytic gastritis.
    • Pancreatic enzyme secretion was inert, and gallbladder function showed hypokinesia or atony.
    • Liver pathology included hypertransaminasemia and steatohepatitis.

    Conclusions:

    • Gastric changes in new-onset CD may promote ulcer formation.
    • Impaired pancreatic exocrine function, gallbladder hypokinesia, and liver dysfunction contribute to significant maldigestion and malabsorption in CD patients.
    Abstract

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