Search for association between suicide and 5-HTT, MAOA and DAT polymorphism in Polish males

A better understanding of genetic determinants of suicidal behavior might be very useful in clinical practice. The objectives of the present study were to answer the question whether there is an association between functional polymorphic forms of 5-HTT, MAOA or DAT and suicidality, and to examine whether the combination of functional alleles in 5-HTT, MAOA and DAT genes would predict a predisposition to suicidal behavior. Functional polymorphisms in 5-HTT, MAOA and DAT genes were investigated in 66 male suicide completers and 51 male control subjects from the Polish population. There were no significant differences in the allele and genotype frequencies between the case and control group. In the individual genotype tests, examination of the distribution differences of each genotype showed that genotype (3;12-12;S-S;9-10) differed between the suicide victims and control subjects. This genotype existed only in the control sample and appeared with the frequency of 8% (p = 0.03).