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Updated: Jun 2, 2026
06:55
Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
Published on: October 26, 2016
Current and future drug-eluting coronary stent technology.
Alfonso Ielasi1, Azeem Latib, Antonio Colombo
1Interventional Cardiology Unit, San Raffaele Scientific Institute, 20100, Milan, Italy.
Expert Review of Cardiovascular Therapy
|April 27, 2011
Summary
Newer drug-eluting stents aim to improve long-term safety and reduce stent thrombosis by optimizing stent platforms, polymers, and drugs. This review covers clinical trials and future development of these advanced coronary devices.
Area of Science:
- Cardiovascular Medicine
- Biomaterials Science
- Interventional Cardiology
Background:
- Drug-eluting stents (DES) offer significant benefits but raise concerns regarding long-term safety, specifically stent thrombosis.
- Potential causes include delayed endothelialization, hypersensitivity, and endothelial dysfunction linked to polymer coatings and drugs.
Purpose of the Study:
- To critically review clinical trials and the current status of next-generation drug-eluting stents.
- To explore future perspectives for the development of safer and more biocompatible coronary devices.
Main Methods:
- Review of key clinical trials and preclinical evaluations of new coronary devices.
- Analysis of advancements in stent platform, polymer, and drug optimization for drug-eluting stents.
Main Results:
- Next-generation DES are being developed to enhance safety and biocompatibility.
- Optimization of stent components is crucial for mitigating adverse events like stent thrombosis.
Conclusions:
- Continued development of drug-eluting stents focuses on improving long-term safety and patient outcomes.
- Future research should address the optimization of stent platforms, polymers, and drugs to minimize risks.
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