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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

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Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Virtual screening against obesity.

P Markt1, S Herdlinger, D Schuster

  • 1Chemical Screening and PLACEBO, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14/AKH BT 25.3, 1090 Vienna, Austria. pmarkt@cemm.oeaw.ac.at

Current Medicinal Chemistry
|April 27, 2011
PubMed
Summary
This summary is machine-generated.

Drug discovery for obesity is advancing with virtual screening. This review covers obesity targets, computational methods, and successful studies to guide future anti-obesity drug development.

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Area of Science:

  • Pharmacology
  • Computational Chemistry
  • Drug Discovery

Background:

  • Obesity is a major global health concern requiring new therapeutic strategies.
  • Drug research for obesity has increasingly adopted computational approaches.
  • Understanding obesity-related protein targets is crucial for effective treatment.

Purpose of the Study:

  • To review the role of virtual screening in anti-obesity drug development.
  • To introduce key obesity targets and computer-aided drug design (CADD) techniques.
  • To highlight successful virtual screening studies and suggest future research directions.

Main Methods:

  • Review of existing literature on virtual screening for anti-obesity drugs.
  • Introduction to computational drug design methodologies.
  • Analysis of successful virtual screening case studies.

Main Results:

  • Virtual screening has proven effective in identifying potential anti-obesity drug candidates.
  • Several protein targets involved in obesity have been identified and validated.
  • Successful studies demonstrate the utility of CADD in accelerating drug discovery.

Conclusions:

  • Virtual screening is a powerful tool for developing novel anti-obesity medications.
  • Continued research into obesity targets and CADD is essential.
  • This review provides a roadmap for future anti-obesity drug development efforts.