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Tumour suppressor function of protein tyrosine phosphatase receptor-T

Anthony Scott1, Zhenghe Wang

  • 1Department of Genetics and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Bioscience Reports
|April 27, 2011
PubMed

Insights

Protein tyrosine phosphatases (PTPs) are tumor suppressors. PTPRT, a frequently mutated PTP in colon cancer, acts as a tumor suppressor, as evidenced by PTPRT knockout mice hypersensitivity to cancer induction.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Protein tyrosine phosphatases (PTPs) are traditionally viewed as tumor suppressors.
  • High-throughput studies reveal loss-of-function mutations in several PTPs in human colon cancers.
  • PTPRT is the most frequently mutated PTP in these cancer genetic analyses.

Purpose of the Study:

  • To review the physiological and pathological roles of PTPRT.
  • To elucidate the cellular pathways regulated by PTPRT.
  • To consolidate evidence for PTPRT's function as a tumor suppressor.

Main Methods:

  • Review of existing literature on PTPRT.
  • Analysis of high-throughput mutational data in human colon cancers.
  • Examination of PTPRT knockout mouse models for cancer susceptibility.

Main Results:

  • PTPRT mutations are common in colon cancer, supporting its tumor suppressor role.
  • PTPRT knockout mice exhibit increased sensitivity to azoxymethane-induced colon cancer.
  • PTPRT regulates key cellular pathways relevant to cancer development.

Conclusions:

  • PTPRT functions as a critical tumor suppressor in the colon.
  • Understanding PTPRT's pathways offers insights into colon cancer pathogenesis.
  • PTPRT represents a potential target for cancer diagnostics or therapeutics.

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