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Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
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Updated: Jun 2, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Technical advances in renal replacement therapy.

Zaccaria Ricci1, Claudio Ronco

  • 1Department of Pediatric Cardiac Surgery, Bambino Gesù Children's Hospital, Rome, Italy.

Seminars in Dialysis
|April 27, 2011
PubMed
Summary
This summary is machine-generated.

Multiple organ dysfunction syndrome (MODS) in critically ill patients can be treated with advanced extracorporeal devices. These machines offer comprehensive support for failing organs and conditions like septic shock.

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Last Updated: Jun 2, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

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Published on: March 27, 2018

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Cardiology
  • Pulmonology
  • Hepatology

Background:

  • Critically ill patients face numerous risks for organ injury, including sepsis and shock, leading to multiple organ dysfunction syndrome (MODS).
  • Acute kidney injury (AKI) is common in intensive care units (ICUs), but MODS involves dysfunction across multiple organs.
  • Current treatments primarily focus on renal replacement therapy (RRT), often insufficient for comprehensive organ support.

Purpose of the Study:

  • To review the technical evolution of multiple organ support therapy (MOST) machines.
  • To discuss the current literature on MOST for critically ill patients.
  • To highlight advancements enabling dedicated pediatric RRT devices.

Main Methods:

  • Review of technical advancements in extracorporeal devices for organ support.
  • Analysis of current literature on the application and efficacy of MOST.
  • Discussion of the development of specialized extracorporeal devices for pediatric patients.

Main Results:

  • Technical evolution has enabled the development of MOST for comprehensive support of multiple failing organs.
  • Extracorporeal devices can now consistently support organs like the liver, heart, and lungs, as well as syndromes like septic shock.
  • Advances may allow for dedicated pediatric RRT devices meeting adult safety standards.

Conclusions:

  • Multiple organ support therapy (MOST) represents a significant advancement in managing critically ill patients with MODS.
  • Extracorporeal technology is expanding to provide holistic organ support beyond traditional RRT.
  • Future developments aim to provide tailored extracorporeal solutions for vulnerable populations, including pediatric patients.