Ovarian hormone action in the hypothalamic ventromedial nucleus: remodelling to regulate reproduction

The ventromedial nucleus of the hypothalamus (VMH) is a major site for the control of female sexual behaviour by ovarian steroid hormones. This review explores recent details that have emerged regarding the ovarian hormone-induced remodelling of neural circuits within the VMH in adult female rats, with the goal of refining the model of the VMH neural circuit. VMH neurones exhibit simple dendritic arbours, with a single long primary dendrite (LPD) and several short primary dendrites. We recently found that ovarian hormones have unanticipated differential effects on the length of the LPDs, suggesting an intricate synaptic reorganisation. LPDs extend into the lateral fibre plexus where they contact oxytocin-labelled terminals. Oestradiol treatment rearranges this oxytocin innervation, in particular by withdrawing some of the LPDs and intensifying the oxytocin input to the remaining dendrites. These changes are reversed with concomitant progesterone treatment. Incorporating these new results, we have updated our working model of hormone-induced synaptic reorganisation in the VMH, emphasising the rebalancing of local versus extrinsic connectivity. The new working model synthesises the recent evidence for rewiring with insights from electrophysiological and behavioural pharmacological studies that pertain to the roles of oxytocin and glutamate in VMH neural activity and mating behaviour.