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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

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Published on: October 25, 2018

Specific immunotherapy in children.

A Bufe1, G Roberts

  • 1Department of Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany. albrecht.bufe@rub.de

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|April 27, 2011
PubMed
Summary
This summary is machine-generated.

Subcutaneous immunotherapy (SCIT) is a common treatment for allergic rhinitis in children, but evidence for its efficacy is limited. Sublingual immunotherapy (SLIT) offers a safer, more convenient alternative, but requires more research on long-term benefits in children.

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Area of Science:

  • Allergy and Immunology
  • Pediatric Pulmonology

Background:

  • Subcutaneous immunotherapy (SCIT) is a standard treatment for allergic rhinitis and asthma in children.
  • While generally safe, SCIT's efficacy in children is less established than in adults.
  • Sublingual immunotherapy (SLIT) presents a potentially safer and more convenient alternative.

Purpose of the Study:

  • To evaluate the current status and future directions of immunotherapy for allergic rhinitis and asthma in children.
  • To compare the efficacy and safety of SCIT and SLIT in pediatric populations.
  • To identify areas requiring further research for SLIT implementation in children.

Main Methods:

  • Review of existing scientific literature on SCIT and SLIT in pediatric allergic diseases.
  • Analysis of evidence regarding long-term efficacy, asthma prevention, and polysensitization.
  • Discussion of safety profiles and compliance issues associated with different immunotherapy routes.

Main Results:

  • SCIT is a routine, safe treatment for pediatric allergic rhinitis and mild-to-moderate asthma.
  • SLIT shows promise for convenience and safety but needs more data on long-term efficacy and asthma prevention in children.
  • Compliance remains a significant challenge for SLIT in pediatric patients.

Conclusions:

  • Immunotherapy, particularly SCIT, can reduce symptoms and medication use in select pediatric asthma patients.
  • Further research is crucial to establish SLIT's long-term benefits and its comparability to SCIT in children.
  • Improving SLIT compliance is essential for its widespread adoption in pediatric allergy care.