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Updated: Jun 2, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Distraction osteogenesis and glossopexy for Robin sequence with airway obstruction
Alan T L Cheng1, Michelle Corke, Alison Loughran-Fowlds
1Department of Otolaryngology, The Children's Hospital at Westmead, Australia. atlcheng@bigpond.com
Insights
Mandibular distraction osteogenesis with glossopexy effectively treated severe obstructive sleep apnea in infants with Robin sequence who did not respond to continuous positive airway pressure (CPAP). This surgical approach avoided the need for tracheostomy.
Area of Science:
- Pediatric Surgery
- Otolaryngology
- Sleep Medicine
Background:
- Robin sequence often presents with severe obstructive sleep apnea (OSA) in infants.
- Continuous positive airway pressure (CPAP) is a common treatment, but can fail in severe cases.
- Surgical intervention may be necessary to manage upper airway obstruction.
Purpose of the Study:
- To evaluate the effectiveness of mandibular distraction osteogenesis with glossopexy in infants with Robin sequence and severe OSA.
- To assess the role of polysomnography (PSG) and endoscopy in managing these patients pre- and post-operatively.
Main Methods:
- Retrospective review of medical records for 20 infants with Robin sequence.
- Analysis of preoperative and postoperative polysomnography (PSG) data.
- Documentation of clinical progress, CPAP therapy, endoscopy findings, and respiratory parameters.
Main Results:
- Six out of 20 infants (30%) with Robin sequence failed CPAP treatment for severe OSA.
- Mandibular distraction osteogenesis with glossopexy successfully managed these six infants, avoiding tracheostomy.
- Associated airway anomalies included hypoplastic epiglottis, laryngomalacia, choanal atresia, and tracheal stenosis.
Conclusions:
- Mandibular distraction osteogenesis with glossopexy is an effective surgical treatment for severe upper airway obstruction in infants with Robin sequence.
- Polysomnography and endoscopy are valuable tools for assessing and managing airway issues in this population.
- Epiglottic maldevelopment was noted in a significant portion of the studied infants.
Background:
We present six cases of infants with Robin sequence and severe obstructive sleep apnoea who failed treatment with nasal mask continuous positive airway pressure (CPAP). Surgical intervention with mandibular distraction osteoneogenesis with glossopexy meant tracheostomy was avoided. Polysomnography (PSG) was used to document the severity of the obstructive sleep apnoea. The aim of this report was to assess the value of mandibular distraction osteogenesis with glossopexy in children with Robin sequence using PSG preoperatively and post-operatively.
Methods:
Retrospective review of medical records to assess details of preoperative clinical progress, CPAP therapy, endoscopy, PSG and respiratory parameters.
Results:
Between 2003 and 2008, 20 infants with Robin sequence were admitted to the neonatal intensive care unit of our tertiary paediatric hospital. Six infants (30%) failed a treatment trial of CPAP during that period, but were subsequently successfully managed with mandibular distraction osteoneogenesis and glossopexy. At endoscopy, all had associated airway problems which included congenitally hypoplastic epiglottis (n= 2), laryngomalacia (n= 2), unilateral choanal atresia (n= 1) and long-segment tracheal stenosis (n= 1).
Conclusion:
Mandibular distraction osteogenesis with glossopexy provides relief of severe upper airway obstruction for infants with Robin sequence. Epiglottic maldevelopment was present in two infants (33%). Endoscopy and PSG assisted clinical management, but highlighted ongoing respiratory issues.
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