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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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[Reduction of the left ventricular mass in essential hypertension patients chronically treated with monotherapy]

H P Baglivo1, G Fabregues, H O Burrieza

  • 1División Cardiología, Policlínica Bancaria, Buenos Aires, Argentina.

Medicina
|January 1, 1990
PubMed

Insights

Essential hypertension patients treated with atenolol, enalapril, or nifedipine showed significant blood pressure and left ventricular mass reduction. These antihypertensive drugs effectively reverse cardiac remodeling in hypertensive individuals.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Context:

  • Essential hypertension is a prevalent condition associated with increased cardiovascular risk.
  • Left ventricular mass (LVM) is a key indicator of cardiac remodeling and a predictor of cardiovascular events.
  • Current antihypertensive therapies aim to reduce blood pressure and prevent target organ damage.

Purpose:

  • To evaluate the effects of single-drug antihypertensive therapy on left ventricular mass in patients with essential hypertension.
  • To compare the efficacy of atenolol, enalapril maleate, and nifedipine in reducing LVM and blood pressure.

Summary:

  • A 12-month study involving 104 patients with mild to moderate essential hypertension compared atenolol, enalapril, and nifedipine against a no-medication control group.
  • All three drugs significantly reduced blood pressure (BP). Atenolol also reduced heart rate, while body weight remained unchanged.
  • Crucially, significant reductions in left ventricular mass (LVM) and the LVM/volume ratio were observed in patients with increased LVM across all treated groups.

Impact:

  • These findings demonstrate that common antihypertensive medications can reverse cardiac hypertrophy in hypertensive patients.
  • The study highlights the importance of LVM assessment in managing hypertension and suggests that effective BP control leads to favorable cardiac remodeling.
  • This research supports the use of atenolol, enalapril, and nifedipine for their beneficial effects on cardiac structure in hypertensive individuals.

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