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Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database
Mary E Platek1, Mihai Merzianu, Terry L Mashtare
1Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA. mary.platek@roswellpark.org
Background:
Olfactory Neuroblastoma is a rare malignant tumor of the olfactory tract. Reports in the literature comparing treatment modalities for this tumor are limited.
Methods:
The SEER database (1973-2006) was queried by diagnosis code to identify patients with Olfactory Neuroblastoma. Kaplan-Meier was used to estimate survival distributions based on treatment modality. Differences in survival distributions were determined by the log-rank test. A Cox multiple regression analysis was then performed using treatment, race, SEER historic stage, sex, age at diagnosis, year at diagnosis and SEER geographic registry.
Results:
A total of 511 Olfactory Neuroblastoma cases were reported. Five year overall survival, stratified by treatment modality was: 73% for surgery with radiotherapy, 68% for surgery only, 35% for radiotherapy only, and 26% for neither surgery nor radiotherapy. There was a significant difference in overall survival between the four treatment groups (p < 0.01). At ten years, overall survival stratified by treatment modality and stage, there was no significant improvement in survival with the addition of radiation to surgery.
Conclusions:
Best survival results were obtained for surgery with radiotherapy.
