Related Experiment Video
Updated: Jun 2, 2026
Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Effect and cost of perioperative use of antibiotics in coronary artery bypass grafting: a randomized controlled study
Zi-Jun Zhou1, Ying-Li Zheng, Yong-Hua Hu
1School of Public Health, Peking University, Beijing 100191, China.
Insights
Implementing antibiotic guidelines for coronary artery bypass grafting (CABG) reduces costs and treatment time without affecting patient outcomes. This strategy optimizes antibiotic use in CABG patients.
Area of Science:
- Cardiovascular Surgery
- Infectious Disease Management
- Pharmacoeconomics
Background:
- Bacterial infections are a significant risk following coronary artery bypass grafting (CABG).
- Perioperative antibiotic use in CABG requires optimization to mitigate complications and costs.
Purpose of the Study:
- To evaluate the effectiveness of a guideline for appropriate perioperative antibiotic use in CABG.
- To assess the impact of the guideline on clinical outcomes, antibiotic duration, and costs.
Main Methods:
- A randomized controlled trial involving 614 patients undergoing CABG.
- Comparison of an intervention group (guideline adherence) with a control group.
- Data collection included hospital stay, antibiotic usage, infection rates, and costs.
Main Results:
- The intervention group showed significantly shorter postoperative hospital stays (P < 0.05).
- Reduced duration of antibiotic use and post-infection treatment time were observed in the intervention group (P < 0.05).
- Lower average daily hospital costs and total antibiotic expenditures were recorded in the intervention group (P < 0.05).
Conclusions:
- The guideline for perioperative antibiotic use in CABG is effective.
- This strategy successfully reduces antibiotic costs and treatment durations.
- Patient clinical outcomes were not compromised by the guideline's implementation.
Background:
Bacterial infections remain a serious complication following coronary artery bypass grafting (CABG). The objective of the study was to determine the effectiveness of a guideline for the appropriate use of antibiotics in CABG during the perioperative period.
Methods:
Six hundred and fourteen hospitalized patients who had undergone CABG from January to June 2006 were randomly allocated to an intervention group and a control group. The data on the hospital stay, days of antibiotic used, types of prophylactic antibiotics used, surgical wound infection and pulmonary infection and antibiotic costs for the patients were compared.
Results:
The postoperative hospitalization days of the intervention group were significantly fewer than that for the control group (P < 0.05). The time of antibiotic use and post-infection treatment time were also significantly less in the intervention group than in the control group (P < 0.05). The average hospital daily cost and total cost of antibiotics were less in the intervention group than in the control group (P < 0.05). Compared with the control group, prophylactic antibiotic use in the intervention group was more reasonable.
Conclusions:
The guideline for the appropriate use of antibiotics in CABG during the perioperative period is effective strategies for reducing antibiotic costs, the time of antibiotic use and post-infection treatment time without compromising the patients' clinical outcome.
