Gender differences in patients undergoing coronary stenting in current stent era

Area of Science:

• Cardiovascular Medicine
• Interventional Cardiology
• Gender Disparities in Health

Background:

• Previous research indicates poorer outcomes for women post-percutaneous coronary intervention.
• The impact of advanced devices like drug-eluting stents (DESs) on gender-specific outcomes remains unclear.
• This study investigates gender differences in hospital and one-year outcomes following coronary stenting.

Purpose of the Study:

• To determine if gender influences hospital and one-year outcomes after coronary stenting.
• To compare the efficacy of bare metal stents (BMS) and DESs in women and men.

Main Methods:

• A single-center study of 969 consecutive patients (250 women, 719 men) undergoing coronary stenting.
• Clinical events were tracked for at least one year post-procedure.
• Analysis included comparison of baseline characteristics and major adverse cardiovascular event (MACE) rates between genders and stent types.

Main Results:

• Women were older and had more comorbidities (diabetes, hypertension, dyslipidemia) than men.
• Hospital MACE rates were significantly higher in women (2.8%) versus men (0.97%) (P=0.037), even after adjustment.
• One-year MACE rates were similar between genders (10.0% women vs. 10.4% men, P=0.874).
• In men, DES significantly improved one-year MACE compared to BMS (P=0.004), but no difference was observed in women.
• Women had a fivefold higher hospital MACE rate than men, but one-year outcomes converged.

Conclusions:

• Women experience a higher rate of adverse cardiovascular events during hospitalization post-coronary stenting compared to men.
• Despite initial disparities, one-year major adverse cardiovascular event rates become comparable between genders.
• Drug-eluting stents demonstrate a long-term benefit in men, but not significantly in women within this study cohort.