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Gender-related differences in mortality after ST-segment elevation myocardial infarction: a large multicentre

Marcin Sadowski1, Mariusz Gasior, Marek Gierlotka

  • 1Swietokrzyskie Centrum Kardiologii, Kielce, Poland. emsad@o2.pl

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|April 27, 2011
PubMed

Insights

Women with ST-segment elevation myocardial infarction (STEMI) face poorer outcomes due to older age and more risk factors, despite not being an independent mortality risk factor. Management and prognosis require further investigation for improved female patient care.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Public Health

Background:

  • Clinical outcomes in acute ST-segment elevation myocardial infarction (STEMI) treatment show disparities between men and women.
  • Understanding these differences is crucial for optimizing patient care and improving survival rates.

Purpose of the Study:

  • To compare the management and clinical outcomes of STEMI between men and women using a large, multicentre national registry.
  • To identify factors contributing to outcome differences in female STEMI patients.

Main Methods:

  • Analysis of data from a one-year national registry involving 456 hospitals.
  • Comparison of demographic, clinical characteristics, treatment received, and in-hospital outcomes between female (n=8,989) and male (n=17,046) STEMI patients.

Main Results:

  • Women were older, had more risk factors, and received percutaneous coronary intervention less frequently than men.
  • Women experienced longer treatment delays and higher rates of in-hospital complications.
  • In-hospital and 12-month mortality were significantly higher in women (11.9% vs. 6.9% and 22% vs. 14.1%, respectively).

Conclusions:

  • While being female is not an independent risk factor for increased long-term STEMI mortality, women present with poorer clinical characteristics and receive less optimal management.
  • Factors such as pulmonary edema, cardiogenic shock, cardiac arrest, age, diabetes, and anterior infarction significantly impact mortality in both sexes.
  • The study highlights the need for tailored management strategies for women with STEMI to address gender-related disparities in outcomes.
Abstract

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