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Published on: January 22, 2019

B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation

Hao Liu1, Christina Tekle, Yih-Wen Chen

  • 1Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604, USA.

Molecular Cancer Therapeutics
|April 27, 2011
PubMed
Summary

B7-H3 protein promotes paclitaxel resistance in breast cancer cells by activating the Jak2/Stat3 pathway. Silencing B7-H3 enhances chemotherapy effectiveness and reduces tumor growth, offering new therapeutic targets.

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