Building excitable membranes: lipid rafts and multiple controls on trafficking of electrogenic molecules

Multiple plasma membrane proteins such as ion transporters and ion channels are involved in electrogenesis by setting resting membrane potentials and triggering/propagating action potentials. Recent findings strongly suggest that some of these membrane proteins are selectively transported into membrane microdomains termed lipid rafts. There appear to be multiple mechanisms for the specific protein translocation to lipid rafts, and many of these proteins exhibit distinct properties when inserted into the raft microdomains. Here the authors review the plasma membrane ion channels specifically localized at membrane lipid rafts in neurons. The mechanisms to selectively translocate these molecules to the lipid rafts and the consequences of the trafficking are also discussed.