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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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TGF-beta-exposed plasmacytoid dendritic cells participate in Th17 commitment

Francis Bonnefoy1, Mélanie Couturier, Amandine Clauzon

  • 1INSERM, Unité Mixte de Recherche 645, F-25020 Besançon Cedex, France.

Journal of Immunology (Baltimore, Md. : 1950)
|April 27, 2011
PubMed
Summary

Transforming growth factor-beta (TGF-β) exposure reprograms plasmacytoid dendritic cells (pDCs) to promote Th17 cell differentiation, not regulatory T cells (Tregs). This involves TGF-β/Smad signaling and increased IL-6 production, impacting autoimmune disease models.

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