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Updated: Jun 2, 2026

Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Filovirus vaccines.

Steven B Bradfute¹, John M Dye, Sina Bavari

¹United States Army Medical Research Institute of Infectious Diseases, National Interagency Biodefense Campus; Fort Detrick, Frederick, MD, USA.

|April 27, 2011

Summary

This summary is machine-generated.

Filoviruses cause deadly hemorrhagic fever, but new vaccines show promise. This review highlights effective filovirus vaccines, particularly those protecting non-human primates, and discusses their development using animal models.

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Last Updated: Jun 2, 2026

Expression and Purification of Virus-like Particles for Vaccination

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Published on: June 2, 2016

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

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Published on: March 2, 2016

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle (VLP)-Based Vaccines Using a Capture Assay

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Published on: February 10, 2022

Area of Science:

Virology
Immunology
Vaccinology

Background:

Filoviruses are a significant public health threat, causing severe hemorrhagic fever in humans and non-human primates (NHPs).
Currently, no clinically approved treatments exist for filovirus infections, necessitating the development of effective countermeasures.
Recent advancements have accelerated the discovery of novel therapeutics and vaccines against filoviruses.

Purpose of the Study:

To review the current literature on filovirus vaccines.
To focus on vaccines demonstrating protection in non-human primate models.
To discuss the role of rodent models and identify correlates of immunity in vaccine development.

Main Methods:

Comprehensive literature search of peer-reviewed publications on filovirus vaccines.
Analysis of studies reporting vaccine efficacy in non-human primate models.
Evaluation of research on rodent models and immunological markers associated with protection.

Main Results:

Multiple vaccine platforms have demonstrated efficacy against filovirus infection in preclinical studies.
Non-human primates serve as a critical model for assessing filovirus vaccine effectiveness.
Rodent models are valuable tools in the early stages of vaccine development, aiding in the identification of immune correlates.

Conclusions:

Significant progress has been made in developing filovirus vaccines, with several candidates showing protective potential.
Non-human primate studies are essential for validating vaccine efficacy and safety.
Further research into correlates of immunity will be crucial for the rational design and licensure of filovirus vaccines.