Related Experiment Video
Updated: Jun 2, 2026
13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology
Lwaki Ebarasi1, Asmundur Oddsson, Kjell Hultenby
1Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Current Opinion in Nephrology and Hypertension
|April 27, 2011
Summary
The zebrafish pronephros is a valuable vertebrate model for studying kidney development and disease. Its use is validated for identifying genes and potential therapies for human kidney conditions.
Area of Science:
- Renal biology
- Comparative physiology
- Developmental biology
Background:
- The zebrafish pronephros serves as a key vertebrate model for kidney research.
- It is utilized for rapid screening of genes impacting kidney physiology and pathophysiology.
- Ongoing characterization validates its relevance for studying human kidney diseases.
Purpose of the Study:
- To review recent advancements in understanding the zebrafish pronephros.
- To highlight its value as a model for human kidney biology and nephropathology.
Main Methods:
- Review of recent scientific literature on zebrafish pronephros research.
- Analysis of genetic and functional studies in zebrafish models.
Main Results:
- Zebrafish pronephros exhibits conserved renal gene structure and function.
- The model allows elucidation of gene roles in kidney biology, overcoming limitations of other systems due to early lethality.
Conclusions:
- Defects in podocyte genes, ion channels, transporters, and cilia mimic human kidney diseases in zebrafish.
- The zebrafish pronephros is a valid system for studying kidney physiology and identifying therapeutic strategies for renal disease.
