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Related Experiment Video

Updated: Jun 2, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

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Published on: November 8, 2015

Managing the risks of immunosuppression.

D Sean Riminton¹, Hans-Peter Hartung, Stephen W Reddel

¹Department of Immunology, Concord Hospital, Concord, Sydney, New South Wales, Australia. sean.riminton@email.cs.nsw.gov.au

Current Opinion in Neurology

|April 27, 2011

Summary

This summary is machine-generated.

New immunomodulating therapies for neuroinflammatory diseases require careful risk management. Patients face increased risks of infections, cancers, and immune system issues, necessitating tailored protocols to optimize treatment benefits.

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Area of Science:

Neuroimmunology
Clinical Risk Management

Background:

Novel immunomodulating treatments for neuroinflammatory diseases are emerging.
These therapies present unique challenges in clinical risk management.

Purpose of the Study:

To review current data on immunosuppression in various clinical contexts.
To guide the assessment and prevention of adverse effects associated with these therapies.
To enhance the benefit-to-risk ratio for patients undergoing treatment.

Main Methods:

Review of recent data on immunosuppression.
Analysis of adverse effects in diverse clinical settings.

Main Results:

Common risks include increased susceptibility to infections, infection-related cancers, and reactivation of latent infections (e.g., herpes viruses, mycobacteria, JC virus).
Additional risks encompass vaccine-preventable diseases, cardiovascular and metabolic issues, and immune dysregulation leading to autoimmune or immune reconstitution inflammatory syndromes.
An online screening tool may aid in patient-specific risk assessment.

Conclusions:

Systematic, patient-tailored risk management protocols are essential.
These protocols will help minimize preventable adverse outcomes.
Optimizing patient benefit from new immunomodifying approaches to neuroinflammatory disease is the ultimate goal.