Related Experiment Video

Updated: Jun 2, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Risk factors for intestinal gangrene in children with small-bowel volvulus

Yu-Pi Lin1, Jung Lee, Hsun-Chin Chao

  • 1Department of Pediatric Gastroenterology, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Journal of Pediatric Gastroenterology and Nutrition
|April 27, 2011
PubMed

Insights

Early diagnosis of pediatric small-bowel volvulus (SBV) is challenging. Clinical signs like nonbilious vomiting and elevated CRP, along with leukocytosis, help identify children with SBV at risk for bowel gangrene.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Diagnostic Imaging

Background:

  • Pediatric small-bowel volvulus (SBV) is a critical surgical condition.
  • Early diagnosis of SBV in children is often difficult, leading to delayed treatment.
  • Identifying risk factors for complications like bowel gangrene is crucial for timely intervention.

Purpose of the Study:

  • To analyze clinical, imaging, and laboratory findings in pediatric SBV cases.
  • To determine risk factors associated with the development of bowel gangrene in children with SBV.
  • To improve diagnostic accuracy and patient outcomes for SBV.

Main Methods:

  • A retrospective analysis of 49 pediatric patients with SBV over 13 years.
  • Evaluation of clinical symptoms (fever, pain, vomiting, dehydration, peritoneal signs) and laboratory data (WBC, CRP, electrolytes, etc.).
  • Statistical comparison of parameters between patients with and without bowel gangrene using univariate and multivariate analyses.

Main Results:

  • Young children (< 5 years) were predominantly affected, with malrotation being the most common cause.
  • Nonbilious vomiting, peritoneal signs, severe dehydration, leukocytosis, elevated CRP, and hyponatremia were linked to bowel gangrene.
  • Multivariate analysis identified nonbilious vomiting, leukocytosis, and elevated CRP as significant predictors of gangrene.

Conclusions:

  • Specific clinical manifestations and laboratory parameters are valuable for identifying bowel gangrene in pediatric SBV.
  • Early recognition of these indicators can guide surgical decisions and potentially reduce complications.
  • While resection rates were significant, no mortality was observed in this cohort.
Abstract

More Related Videos

A Mouse Model of Intestinal Partial Obstruction07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Related Concept Videos

Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...