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Stress hyperglycemia in febrile children: relationship to prediabetes

E U Saz1, S Ozen, D Simsek Goksen

  • 1Department of Pediatric Emergency Medicine, Ege University School of Medicine, Bornova, Izmir, Turkey.

Minerva Endocrinologica
|April 27, 2011
PubMed

Insights

Stress hyperglycemia (SH) in febrile children is linked to severe illness, not prediabetes. Follow-up showed normal glucose metabolism after recovery, indicating SH is a transient condition.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Infectious Diseases

Background:

  • Febrile illnesses can trigger stress hyperglycemia (SH) in children.
  • The relationship between SH and underlying metabolic conditions like prediabetes requires further investigation.

Purpose of the Study:

  • To characterize clinical features and short-term outcomes of SH in febrile children.
  • To assess the association between SH and prediabetes in this pediatric population.

Main Methods:

  • Febrile children presenting to the emergency department were enrolled.
  • Stress hyperglycemia was identified using bedside glucometers and confirmed with laboratory glucose measurements.
  • Illness severity was assessed using the Emergency Severity Index (ESI); prediabetes screening included oral glucose tolerance tests and immunological markers.

Main Results:

  • Of 185 children, 22 had SH. SH was more common in males and those with higher illness severity, sepsis, or central nervous system (CNS) infections.
  • All children with SH recovered without complications.
  • Follow-up revealed normal glucose metabolism and biochemical markers for diabetes.

Conclusions:

  • SH in febrile children is associated with increased illness severity, high fever, sepsis, and CNS infections.
  • No evidence of abnormal glucose metabolism or prediabetes was found after acute illness resolution.
Abstract

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