Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pragmatic, Multicenter, Double-Blind Evaluation of Circulating Cancer-Associated Macrophage-Like Cells for Detection of Cancer in Indeterminate Pulmonary Nodules.

JCO precision oncology·2026

Same author

Theoretical Clinical Utility of Advanced Practice Provider Use of an Artificial Intelligence Radiomics-based Tool for Pulmonary Nodule Evaluation and Management.

CHEST pulmonary·2026

Same author

BMI and Initiation of Cancer Screening: A Closer Look at Differences by Race, Ethnicity, and Sex in a Multicenter Population.

American journal of preventive medicine·2026

Same author

Lung Cancer Yield by Baseline Screening Lung CT Screening Reporting and Data System (Lung-RADS) Assignment and Patient Factors: The Population-Based Research to Optimize the Screening Process Lung Consortium.

CHEST pulmonary·2026

Same author

Cryobiopsy vs Forceps for Bronchoscopic Lung Biopsy: The FROSTBITE-2 Randomized Clinical Trial.

JAMA·2026

Same author

Impact of race and acculturation on lung cancer screening eligibility: a multicenter lung cancer cohort study.

American journal of respiratory and critical care medicine·2026

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Gene therapy for mesothelioma.

Anil Vachani¹, Edmund Moon, Steven M Albelda

¹Thoracic Oncology Research Laboratory, University of Pennsylvania, 1016E Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104-6160, USA. avachani@mail.med.upenn.edu

Current Treatment Options in Oncology

|April 27, 2011

Summary

Gene therapy offers a promising treatment for mesothelioma, a cancer with limited options. Clinical trials show it is safe and potentially effective, with new approaches under investigation.

More Related Videos

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Related Experiment Videos

Last Updated: Jun 2, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Area of Science:

Oncology
Gene Therapy
Mesothelioma Research

Background:

Mesothelioma is a challenging cancer with few effective treatments.
The localized nature and accessibility of mesothelioma tumors make them suitable for gene therapy.
Mesothelial cells provide a large surface area for efficient gene transfer.

Purpose of the Study:

To review existing clinical trials of gene therapy for mesothelioma.
To describe novel gene therapy strategies currently being explored for mesothelioma treatment.

Main Methods:

Systematic review of published gene therapy clinical trials in mesothelioma.
Description of emerging gene therapy techniques and their potential application.

Main Results:

Previous gene therapy trials in mesothelioma have demonstrated acceptable safety profiles.
Some trials have indicated limited but encouraging signs of therapeutic efficacy.
Ongoing research is exploring innovative gene therapy approaches.

Conclusions:

Gene therapy is a viable and promising therapeutic strategy for mesothelioma.
Further research and clinical trials are warranted to optimize gene therapy efficacy for mesothelioma patients.