GEIRA: gene-environment and gene-gene interaction research application
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Updated: Jun 2, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Bo Ding1, Henrik Källberg, Lars Klareskog
1Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Box 210, Stockholm, Sweden. Bo.Ding@ki.se
Abstract:
The GEIRA (Gene-Environment and Gene-Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene-gene interaction analysis. It implements concepts of both additive and multiplicative interaction as well as calculations based on dominant, recessive and co-dominant genetic models, respectively. Estimates of interactions are incorporated in a single table to make the output easily read. The algorithm is coded in both SAS and R. GEIRA is freely available to non-commercial users at http://www.epinet.se. Additional information, including user's manual and example datasets is available online at http://www.epinet.se.
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