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Published on: May 12, 2020
Evaluation of oxidative status in patients with hyperthyroidism
Mehmet Aslan1, Niyet Cosar, Hakim Celik
1Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey. m.aslan301@mynet.com
Endocrine
|April 27, 2011
Summary
Hyperthyroidism patients show decreased total antioxidant capacity (TAC) and increased total oxidant status (TOS), indicating heightened oxidative stress. This imbalance may contribute to the condition, suggesting antioxidant supplementation could be beneficial.
Area of Science:
- Endocrinology
- Biochemistry
- Oxidative Stress Research
Background:
- Limited and conflicting data exist on antioxidant enzyme levels in hyperthyroidism.
- Oxidative status evaluation is crucial for understanding hyperthyroid pathogenesis.
Purpose of the Study:
- To evaluate the oxidative status in hyperthyroid patients using an automated method.
- To assess the relationship between oxidative stress markers and thyroid hormone levels.
Main Methods:
- Compared 36 hyperthyroid patients with 30 healthy controls.
- Measured serum total antioxidant capacity (TAC), total oxidant status (TOS), and calculated oxidative stress index (OSI) using an automated method.
Main Results:
- Hyperthyroid patients had significantly lower TAC (P=0.002) and higher TOS (P=0.008) and OSI (P=0.004) compared to controls.
- TAC, TOS, and OSI correlated significantly with TSH, FT3, and FT4 levels.
- Disease duration correlated with OSI (P=0.011).
Conclusions:
- Hyperthyroidism is characterized by increased oxidants and decreased antioxidants, shifting the balance towards oxidative stress.
- Elevated oxidative stress may play a role in hyperthyroid pathogenesis.
- Antioxidant vitamin supplementation (e.g., C and E) may benefit hyperthyroid patients.
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