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Updated: Jun 2, 2026
Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Assessing renal function with a rapid, handy, point-of-care whole blood creatinine meter before using contrast
Satoru Morita1, Kazufumi Suzuki, Ai Masukawa
1Department of Radiology, Tokyo Women's Medical University, Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan. i@imodey.com
Purpose:
The aim of this prospective study was to assess the reliability of a rapid, handy, point-of-care whole blood creatinine meter (PCM) in patients who were scheduled to undergo contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI).
Materials And Methods:
Among patients scheduled to undergo contrast-enhanced CT or MRI examinations, 113 patients who did not have creatinine data from the prescribed intervals before the examination day (in principle, 90 days for scheduled outpatients and 7 days for inpatients and urgent patients) were included. The estimated glomerular filtration rate (eGFR) was calculated using the creatinine values measured with the PCM and those from central laboratory measurements (LAB). The two eGFR values were compared statistically with the paired t-test, Pearson's correlation coefficient, and the Bland-Altman analysis.
Results:
The mean eGFR measured with the PCM was slightly higher than the LAB value (81.2 ± 24.6 vs. 70.2 ± 19.7 ml/min/1.73 m(2), P < 0.0001). They were well correlated (r = 0.74, y = 0.92x + 16.9, P < 0.0001). Bland-Altman plots (mean difference was 11.0 ml/min/1.73 m(2); limits of agreement were -22.4 to +44.4 ml/min/1.73 m(2)) showed a moderate agreement with some degree of dispersion.
Conclusion:
The PCM can rapidly assess renal function using a small amount of blood almost equally to that of determined in the laboratory, which may help reduce the risk of contrast material-induced complications.
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