Related Experiment Video

Updated: Jun 2, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

[Cecal perforation in a kidney transplant patient: disseminated histoplasmosis]

N Kourda1, M Mlika, Y S H Zidi

  • 1Département d'Anatomie Pathologique, Hôpital Charles Nicolle, Tunis, Tunisie.

Medecine Tropicale : Revue Du Corps De Sante Colonial
|April 28, 2011
PubMed

Insights

Disseminated histoplasmosis, a fungal infection, can affect kidney transplant patients. This case highlights a fatal outcome due to delayed diagnosis of cutaneous and digestive involvement.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Disseminated histoplasmosis is a severe fungal infection caused by Histoplasma capsulatum, primarily affecting immunocompromised individuals.
  • The infection presents in large- and small-celled variants and can manifest with diverse clinical symptoms.

Observation:

  • A case report of a Senegalese man who developed disseminated histoplasmosis with cutaneous and digestive involvement four years post-kidney transplantation.
  • The patient presented with severe sepsis resulting from colonic perforation.

Findings:

  • The patient's disseminated histoplasmosis involved both skin and gastrointestinal tract.
  • Delayed diagnosis and the advanced stage of the infection contributed to a fatal outcome.

Implications:

  • This case underscores the importance of considering disseminated histoplasmosis in immunocompromised patients, particularly transplant recipients, presenting with unusual symptoms.
  • Early diagnosis and prompt treatment are crucial for improving outcomes in disseminated histoplasmosis.
  • Highlights the need for heightened awareness of fungal infections in organ transplant recipients, especially in endemic regions.

More Related Videos

Murine Kidney Transplant Technique08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...