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Related Experiment Video

Updated: Jun 2, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

Full-field 3D photoacoustic imaging based on plane transducer array and spatial phase-controlled algorithm.

Qiuzhen Zhou¹, Xuanrong Ji, Da Xing

¹MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Medical Physics

|April 28, 2011

Summary

This summary is machine-generated.

A new spatial phase-controlled algorithm enhances photoacoustic imaging (PAI) efficiency. This method uses a single laser shot for 3D reconstruction, improving safety and speed for clinical applications.

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Published on: November 4, 2014

Area of Science:

Biomedical Imaging
Optical Physics
Medical Technology

Background:

Photoacoustic imaging (PAI) offers noninvasive biological tissue visualization.
Current PAI methods require multiple laser shots and signal acquisitions, limiting efficiency and potentially causing tissue damage.
Improving PAI efficiency is crucial for broader clinical adoption.

Purpose of the Study:

To develop a novel, more efficient PAI approach for clinical applications.
To increase the speed and safety of 3D photoacoustic imaging.

Main Methods:

A spatial phase-controlled algorithm was developed for full-field 3D image reconstruction.
The algorithm enables reconstruction from a single laser shot data acquisition.
An unfocused plane transducer array and parallel data-acquisition (PDA) system were employed for signal detection.

Main Results:

The system demonstrated capability for static and dynamic 3D PAI.
Successful imaging of graphite rods in simulations and rabbit ear vessels was achieved.
Dynamic capture of particle motion in fluid was also demonstrated.

Conclusions:

The spatial phase-controlled algorithm, coupled with a plane transducer array and PDA, allows 3D PAI reconstruction from single-pulse excitation.
This approach reduces light exposure, enhancing safety for in vivo imaging.
Real-time 3D imaging is achievable with increased laser repetition rates and display speeds, promising significant clinical diagnostic value.