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Levan nanostructured thin films by MAPLE assembling.

Felix Sima1, Esra Cansever Mutlu, Mehmet S Eroglu

  • 1Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, Ilfov, RO-77125, Romania.

Biomacromolecules
|April 28, 2011
PubMed
Summary

Researchers synthesized pure and oxidized levan exopolysaccharide nanostructured thin films using laser evaporation. Oxidized levan films exhibited enhanced hydrophilicity and superior cell proliferation potential, indicating promising biomaterial applications.

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Corrigendum to "Functional bread containing synbiotic microcapsules loaded with Lactobacillus delbrueckii subsp. bulgaricus and enzymatic levan" [Food Chem. 511 (2026) 148823].

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Nanotechnology

Background:

  • Exopolysaccharides like levan are biocompatible polymers with potential applications in tissue engineering and drug delivery.
  • Developing methods for creating nanostructured thin films of exopolysaccharides is crucial for advanced material design.
  • Surface modification of biomaterials can significantly alter their properties, such as hydrophilicity and cell interaction.

Purpose of the Study:

  • To synthesize nanostructured thin films of pure and oxidized levan exopolysaccharide.
  • To investigate the structural, chemical, and surface properties of the synthesized films.
  • To evaluate the in vitro cell proliferation potential of the levan-based coatings.

Main Methods:

  • Matrix-assisted pulsed laser evaporation (MAPLE) was employed using a KrF* excimer laser source.

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  • Cryogenic pellets of levan exopolysaccharide in dimethyl sulfoxide were used as targets.
  • Surface characterization included contact angle measurements, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and atomic force microscopy (AFM).
  • In vitro colorimetric assays were performed to assess cell proliferation.

    • Main Results:

    • Nanostructured thin films of both pure and oxidized levan were successfully synthesized.
    • Oxidized levan films demonstrated increased hydrophilicity due to the formation of acidic aldehyde-hydrogen bonds.
    • FTIR confirmed the preservation of levan's chemical composition in the films.
    • SEM and AFM revealed compact film structures with high specific surface areas.
    • All coatings supported cell proliferation, with oxidized levan showing a slight advantage.

    Conclusions:

    • Matrix-assisted pulsed laser evaporation is an effective technique for producing nanostructured levan exopolysaccharide thin films.
    • Oxidation enhances the hydrophilic properties of levan films, making them potentially more suitable for certain biomedical applications.
    • The synthesized levan films exhibit excellent biocompatibility and promote cell proliferation, highlighting their potential as advanced biomaterials.