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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light bulb,...
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Retrieval

Retrieval is the process of getting information out of memory storage and back into conscious awareness. This ability is essential for daily tasks like brushing hair and teeth, driving to work, and performing job duties. Retrieval occurs in three ways: recall, recognition, and relearning.
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Light Acquisition02:16

Light Acquisition

In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
Water and Mineral Acquisition02:34

Water and Mineral Acquisition

Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.

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The ACQUIRE trial.

Guido Grassi1

  • 1Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Ospedale San Gerardo, Università Milano-Bicocca, Ospedale S. Gerardo dei Tintori, Via Pergolesi 33, 20052 Monza (Milan), Italy. guido.grassi@unimib.it

Expert Opinion on Pharmacotherapy
|April 28, 2011
PubMed
Summary
This summary is machine-generated.

Achieving target blood pressure remains challenging, especially for high-risk patients. The ACQUIRE study found aliskiren combined with hydrochlorothiazide effectively controls hypertension and improves patient adherence.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension management, particularly achieving goal blood pressure in high-risk patients, remains a significant clinical challenge.
  • Patient adherence to antihypertensive medications is crucial for effective blood pressure control.

Discussion:

  • The ACQUIRE study assessed aliskiren monotherapy versus aliskiren/hydrochlorothiazide combination in stage 2 hypertensive patients, including those with obesity.
  • The combination therapy demonstrated superior efficacy in achieving satisfactory blood pressure control, especially for systolic values, which are critical for cardiovascular risk.
  • The combination regimen provided early blood pressure control with a favorable safety profile, leading to high treatment adherence.

Key Insights:

  • Aliskiren/hydrochlorothiazide combination therapy is highly effective for stage 2 hypertension, including obese patients.
  • Early and sustained blood pressure control is achievable with combination therapy.
  • Improved safety and adherence are associated with the combination regimen.

Outlook:

  • Further research may explore long-term cardiovascular outcomes with this combination therapy.
  • This regimen offers a promising strategy for managing difficult-to-control hypertension.
  • Optimizing adherence through effective combination therapies is key to reducing hypertension-related morbidity.