Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing insoluble type II collagen microfiber scaffolds for cartilage tissue engineering.

Biomaterials advances·2026
Same author

Tryptophan Metabolism in Alzheimer's Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis.

Aging and disease·2024
Same author

Burden evaluation and prediction of osteoarthritis and site-specific osteoarthritis coupled with attributable risk factors in China from 1990 to 2030.

Clinical rheumatology·2024
Same author

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.

Cellular and molecular life sciences : CMLS·2024
Same author

N-Acetylserotonin Alleviates Retinal Autophagy via TrkB/AKT/Nrf2 Signaling Pathway in Retinal Ischemia-Reperfusion Injury Rats.

Ophthalmic research·2023
Same author

The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke.

Journal of pineal research·2023

Related Experiment Video

Updated: Jun 2, 2026

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

From bone to brain: human skeletal stem cell therapy for stroke.

Shuanhu Zhou1

  • 1Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. szhou@rics.bwh.harvard.edu

Central Nervous System Agents in Medicinal Chemistry
|April 28, 2011
PubMed
Summary

Human skeletal stem cells (MSCs) can differentiate into various cell types and show promise for stroke treatment. However, MSC aging poses challenges for elderly patients receiving autologous cell therapy.

More Related Videos

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells
05:49

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells

Published on: April 13, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells
05:49

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells

Published on: April 13, 2018

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Neuroscience

Background:

  • Human adult skeletal stem cells, also known as mesenchymal stem cells (MSCs), are multipotent cells capable of differentiating into various cell types.
  • MSCs can differentiate into mesenchymal lineages (osteoblasts, chondrocytes, adipocytes) and non-mesenchymal lineages (neurons, glial cells).
  • Adult stem cell transplantation is a promising therapeutic strategy for stroke treatment.

Purpose of the Study:

  • To review recent advancements in human skeletal stem cell biology.
  • To discuss the in vitro differentiation of MSCs into neural lineages.
  • To explore MSC therapy for stroke, including challenges related to MSC aging and autologous cell therapy in elderly patients.

Main Methods:

  • Literature review of recent progress in human skeletal stem cell biology.
  • Analysis of studies on in vitro differentiation of MSCs into neural stem cells and neurons.
  • Examination of research on MSC therapy for stroke.

Main Results:

  • MSCs exhibit plasticity, differentiating into diverse cell types, including neural cells.
  • MSC transplantation is a viable therapeutic approach for stroke.
  • MSC aging presents a significant hurdle for autologous cell therapy in elderly stroke patients.

Conclusions:

  • Human skeletal stem cells (MSCs) hold significant therapeutic potential for stroke.
  • Further research is needed to overcome challenges associated with MSC aging for effective autologous cell therapy in stroke patients.