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Related Experiment Video

Updated: Jul 13, 2026

Assay for Adhesion and Agar Invasion in S. cerevisiae

Assay for Adhesion and Agar Invasion in S. cerevisiae

Published on: November 8, 2006

abaA controls phialide differentiation in Aspergillus nidulans.

T C Sewall¹, C W Mims, W E Timberlake

¹Department of Plant Pathology, University of Georgia, Athens 30602.

|August 1, 1990

Summary

The abacus A (abaA) gene is crucial for Aspergillus nidulans development. Loss of abaA function prevents conidia formation, leading to abnormal structures instead of specialized phialides.

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Quantitative Analysis of Aspergillus nidulans Growth Rate using Live Microscopy and Open-Source Software

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Published on: July 24, 2021

Area of Science:

Mycology
Developmental Biology
Genetics

Background:

Aspergillus nidulans reproduces asexually via conidiophores and conidia.
The regulatory locus abacus A (abaA) is essential for normal conidiophore development.
Mutations in abaA lead to aberrant conidiophores that fail to produce conidia.

Purpose of the Study:

To investigate the ultrastructural defects in conidiophore development caused by abaA mutations.
To determine the role of abaA+ in phialide differentiation and maintenance.

Main Methods:

Ultrastructural examination of conidiophore development in an abaA- mutant strain.
Temperature shift experiments using a temperature-sensitive abaA14ts mutant strain.

Main Results:

In abaA- mutants, metulae formed supernumerary tiers of metula-like cells instead of phialides.
abaA+ function induced phialide formation in aberrant cells.
Continuous abaA+ activity was necessary for maintaining phialide function.

Conclusions:

The abacus A (abaA)+ gene directs the differentiation of phialides in Aspergillus nidulans.
abaA+ is continuously required for the maintenance of phialide function during asexual reproduction.